December 14, 2020 /Sports News – Local Utah Football Standouts Net Weekly Pac-12 Honors FacebookTwitterLinkedInEmailSAN FRANCISCO-Because of their contributions in helping Utah upset Colorado Saturday, a pair of Utes football standouts received recognition from the Pac-12 Monday.Freshman tailback Ty Jordan and sophomore placekicker Jadon Redding were named as the conference’s freshman and special teams player of the week respectively.In the Utes’ 38-15 rout of then-No. 21 Colorado at Boulder, Colo., Jordan ran for 147 yards (8.6 yards per carry) and two scores against the Buffaloes.Jordan, a native of Mesquite, Texas, ranks eighth in the FBS and first in the Pac-12 in yards per carry (7.3) and ranks 15th in the subdivision in rushing yards per contest (110.8 yards per game).Saturday, Redding symmetrically scored 12 points for the second consecutive week, netting three field goals and three PATs against the Buffaloes.Redding is a native of Fredericksburg, Va. Written by Brad James Tags: Utah Football
ARLA and the NAEA have welcomed their new presidential teams for the year ahead. Nik Madan succeeds Peter Savage as President of ARLA, and Sally Lawson is appointed ARLA’s President Elect.Nik has 20 years’ lettings experience, including 12 years at John D Wood & Co. in Central London and he is now Group Lettings Director at Connells Group.David Mackie succeeds Martyn Baum as President of NAEA, while Katie Griffin becomes NAEA’s President Elect. David has 25 years’ experience in the residential property market, as an estate agent, letting agent and consultant. He has also held various roles with NAEA including deputy Member Advisory Forum representative and chairman of the Scottish branch of NAEA.New President NAEA ARLA August 19, 2016The NegotiatorWhat’s your opinion? Cancel replyYou must be logged in to post a comment.Please note: This is a site for professional discussion. Comments will carry your full name and company.This site uses Akismet to reduce spam. Learn how your comment data is processed.Related articles Letting agent fined £11,500 over unlicenced rent-to-rent HMO3rd May 2021 BREAKING: Evictions paperwork must now include ‘breathing space’ scheme details30th April 2021 City dwellers most satisfied with where they live30th April 2021 Home » News » Associations & Bodies » New Presidents take the reins previous nextAssociations & BodiesNew Presidents take the reinsThe Negotiator19th August 20160549 Views
The Mondial Forni Rotor Wide rotating rack, forced convection oven, from Eurobake (Bolton, Lancashire), features a rotating rack and bottom-to-top air distribution to give consistent baking, says the company.The load rack system can handle single or double racks up to 80cm x 100cm with a baking surface from 6.3 to 14.4sq m. The new electronic control panel makes it possible to programme up to nine operating phases for each recipe.
William Reed Business Media, the publisher of British Baker, has partnered with Virtual College, the leading provider of e-learning and online training, to offer a range of materials for the food industry.With 150 years’ experience, William Reed Business Media has an expanding portfolio of websites, virtual events and data services which ensures global food industry customers continue to benefit from excellence in information provision. With over 1.6 million online learners, Virtual College is one of the UK’s leading developers of e-learning online, providing courses to individuals and companies across the world.The new business entity will be known as Appetite Learning and will be the exclusive supplier of the existing Virtual College portfolio of courses to the food sector, as well as developing a range of new e-learning materials.Charles Reed, group managing director of William Reed Business Media, said: “The creation of Appetite Learning represents a significant expansion in our digital solutions for the food industry. I’m very pleased to be partnering with an e learning business with Virtual College’s outstanding reputation and proven excellence in technology and content development.”And, Rod Knox, chief executive of Virtual College, added: “William Reed is a perfect partner for Virtual College, with outstanding customer relationships across the food, drink and hotel markets. Our shared aspiration is for Appetite Learning, in partnership with Virtual College, to be the leading training provider for the sector.“This is a really exciting development and is a fundamental part of a wider business growth strategy for the next three years.”
Because AML originates in the bone marrow and cancerous cells can “hide” there to escape chemotherapy treatment, the team analyzed the mice’s bone marrow. They found large numbers of active T cells and no trace of AML cells in the cryogel-vaccinated mice’s marrow. When they transplanted bone marrow from those mice into healthy mice that were then challenged with AML cells, all of the transplant recipients survived while a control group of mice succumbed to AML within 30 days, indicating that the immune protection against AML was sustained and transferable.Unexpected results, better-than-expected outcomesTo more closely mimic the clinical scenario of a human patient developing AML, the team injected their cryogel vaccine into mice that had AML along with the standard chemotherapy regimen that AML patients receive, which causes fast-dividing AML cells to die in large numbers. The activated T cell response in mice that received the combo therapy was six-fold higher than in mice that received chemo plus a traditional liquid vaccine, suggesting that the cryogel was a much more effective vehicle for delivering the activating biomolecules to the immune system.To test the durability of the immune response generated by the combo treatment, they harvested bone marrow from mice that were given the cryogel vaccine with WT-1 peptide along with chemotherapy and transplanted it into healthy mice. None of the recipient mice developed AML for up to 14 days after transplant, indicating that the combo-treated donor mice did not have residual AML cells in their marrow. All the recipient mice also survived a later challenge with AML cells, while mice that did not receive donor bone marrow died within 31 days.But, when the researchers started to tinker with the vaccine’s components to investigate why it worked so well, they saw something completely unexpected: vaccines that had no AML antigen in them were just as effective at providing protection as vaccines containing either AML cell contents or WT-1 peptide.“We were definitely surprised and really didn’t expect this result, because we initially thought that including the antigen in the vaccine was critical. That led us down some research avenues we hadn’t previously considered to try and understand what was going on,” said co-first author Alex Najibi, a graduate student in the Mooney lab. “We found that AML cells actually enter the cryogels over time, right where dendritic cells are already concentrated and activated. When the chemo causes large numbers of AML cells to die, the dendritic cells can pick up their remains as antigens and generate a strong signal to activate T cells against AML.”To further evaluate the efficacy of their antigen-free vaccine and chemotherapy combo, the team analyzed the bone marrow of mice with AML that received either the combo or the antigen-free vaccine alone. They found that the antigen-free vaccine alone did not effectively reduce the amount of AML cells in the marrow or increase the number of active T cells, but the combo therapy achieved both of those goals. The combo also caused a decline in the number of regulatory T cells (Tregs) in the marrow, which suppress immune function and are thought to be a major reason why AML cells in the marrow can evade immune detection.Work on the cryogel vaccine is continuing along multiple threads of inquiry. Mooney’s team is examining how it could be combined with sequencing technology to identify antigens that are specific to a single patient’s cancer and create a highly personalized vaccine, and also exploring potential synergies with T cell and other adoptive transfer techniques. Other members of the lab are researching antigen-free vaccines in the context of breast cancer, as well as further investigating the response they observed in AML.“We are very excited about the performance of our AML vaccine, because it could finally provide long-term, relapse-free survival for AML patients, either to ‘clean up’ residual AML cells in the bone marrow following a stem cell transplant, or in older patients who cannot tolerate either transplants or high-dose chemo,” said Mooney, who is also the Founding Core Faculty & Lead of the Immuno-Materials platform at the Wyss Institute at Harvard University and the Robert P. Pinkas Family Professor of Bioengineering at SEAS.Additional authors of the paper include Ting-Yu Shih and Angelo Mao from the Wyss Institute and SEAS, and David Scadden and Azeem Sharda from the Department of Stem Cell and Regenerative Biology at Harvard University and the Harvard Stem Cell Institute.This research was supported by the National Institutes of Health, the Cancer Research Institute, and the National Science Foundation. Acute myeloid leukemia (AML) is a deadly blood cancer that originates in the bone marrow and kills most of its victims within five years. Chemotherapy has been the standard AML treatment for over 40 years, and while it often causes the cancer to go into remission, it rarely completely eliminates the cancerous cells, which then lead to disease recurrence in nearly half of treated patients. Aggressive post-remission treatments, like high-dose chemotherapy or bone marrow transplants, can reduce the chance of recurrence, but many AML patients are not healthy enough to tolerate them.Now, a new study presents an alternative treatment that has the potential to eliminate AML cells completely: an injectable, biomaterial-based vaccine that, when combined with standard chemotherapy, caused complete and lasting recovery from and immunity against AML in mice. The study was conducted by researchers from Harvard’s Wyss Institute for Biologically Inspired Engineering, the Harvard John A. Paulson School of Engineering and Applied Sciences (SEAS), and the Harvard Stem Cell Institute (HSCI), and is published in Nature Biomedical Engineering.“We have previously developed cancer vaccines against solid tumors, and we were curious to see if this technology would also be effective at treating a blood cancer like AML,” said co-first author Nisarg Shah, a former postdoctoral fellow in the lab of Wyss core faculty member David Mooney, who is now an assistant professor at the University of California, San Diego. “The promising outcomes of the combination of this vaccine with chemotherapy may translate to human vaccines that can be personalized yet offer off-the-shelf convenience.”A crafty cryogelLike other vaccines, the AML vaccine “teaches” the body’s immune system to recognize a foreign invader (in this case, AML cancer cells) so that it can mount an effective attack when that invader appears. While traditional vaccines are typically liquid, this vaccine is a tiny, disk-shaped “cryogel” scaffold made primarily of two materials – polyethylene glycol and alginate – that have been cross-linked together to form a matrix. Two biomolecules (GM-CSF and CpG-ODN) are embedded in the scaffold to attract the body’s dendritic cells and activate them, along with antigens specific to AML cells (either contents from dead AML cells or a peptide from the protein WT-1 that AML cells express on their surface). The activated dendritic cells take up the antigens from the vaccine site and present them to T cells, triggering them to seek and destroy AML cells and, hopefully, patrol the body long-term to destroy any disease recurrence.To test whether their cryogel vaccine effectively primed the immune system to attack AML cells, the team injected it under the skin of healthy mice, and saw that it resulted in a much higher number of activated T cells when either AML cell contents or WT-1 peptide was used as the antigen, compared with mice that received the activating biomolecules via a traditional vaccine injection or a “blank” scaffold without any biomolecules. They then “challenged” the mice by injecting them with WT-1-expressing AML cells to mimic the initial onset of the disease. The mice that received either the traditional vaccine or a blank scaffold succumbed to the disease within 60 days, while those that received the cryogel vaccine survived. The survivors were then re-challenged with a second dose of AML cells after 100 days and displayed no signs of disease, demonstrating that the vaccine successfully protected them against recurrence. “The promising outcomes of the combination of this vaccine with chemotherapy may translate to human vaccines that can be personalized yet offer off-the-shelf convenience.” — David Mooney
James Lyphout, Notre Dame’s vice president for Business Operations, will retire in June, according to a University press release. Lyphout is the University’s longest-serving current officer. Notre Dame’s Board of Trustees elected him vice president in 1999. He also served as assistant vice president for Business Affairs from 1984 to 1996 and as associate vice president for business operations from 1996 to 1999. In his current position, Lyphout oversees campus infrastructure and construction projects, the Office of Sustainability, campus operations and most auxiliary campus operations such as food services, the Hammes Notre Dame Bookstore and the Morris Inn. He also manages Notre Dame’s London Centre, the Keough-Notre Dame study Centre in Dublin and the Hank Environmental Research Center at Land O’Lakes, Wis. “Jim Lyphout has provided outstanding leadership to the essential services that comprise the University’s core infrastructure,” Executive Vice President John Affleck-Graves said in the press release. “During his tenure, our student dining services have consistently been rated among the finest in the country, our campus planning and construction programs are held up as best examples of the application of gothic architecture in an academic environment, and we have continued to enhance the natural beauty of our campus through our tree planting and campus landscaping projects.” As vice president for Business Operations, Lyphout has overseen around 20 construction projects, the ongoing renewal of Notre Dame Stadium, several renovation projects and the closure of Juniper Road through campus. “It has been my privilege and honor to serve for the last 27 years as a member of the University administration,” Lyphout said in the press release. “During my tenure, I have enjoyed being an integral part of the remarkable growth in campus building space of more than 20 percent. This growth was guided by the campus master plan, crafted by a wonderful team of colleagues and designed to direct all future development of campus.” Lyphout is a native of East Moline, Ill. He earned both bachelor’s and master’s degrees from Western Illinois University, served in the U.S. Army from 1970 to 1972 and worked at Northwestern University before coming to Notre Dame. He and his wife, Rose have two sons who are Notre Dame graduates.
A group of drug traffickers decided to exploit the Christmas spirit and hid a shipment of cocaine among toys and candy to be donated to poor children in Nicaragua. The drugs were seized during Christmas week at an inspection post on the border with Costa Rica, the Nicaraguan police said. “It was a donation that was being sent to Nicaraguan children. There are no links between the people shipping the drugs and the people who sent the donation,” said Esteban Guido, a senior commissioner in the Nicaraguan national police. The drugs, 334 kilos of cocaine hidden among 50 bags of candy and 250 bags of toys, were being transported in two trucks with Guatemalan and Nicaraguan license plates. “We’ve spoken with the Costa Rican authorities, and they’ve cooperated with us. The drugs are linked to wholesale dealers in Costa Rica,” he explained. For years, Central America has been a transit route for South American cocaine, but the powerful Mexican cartels have recently increased their presence in the region in response to the military campaign they are facing in their own country. According to analysts, Mexican cartels are buying land, warehousing drugs and weapons, and contracting Nicaraguan gang members to sell narcotics. Guido said that the case is still under investigation and has not been linked to any particular cartel. By Dialogo December 29, 2010
Land use section takes up GVV Land use section takes up GVV Making recommendations on a case involving quasi-judicial government actions and a Bar rule have been occupying the Environmental and Land Use Law Section.Chair Sid Ansbacher, at the section’s executive council meeting held during the recent Bar convention, said the council set up an ad hoc committee to examine the implications of the case known as GVV, a Florida Supreme Court matter which posed a question to the Appellate Rules Committee over whether governments had to make findings of facts in quasi-judicial proceedings, such as zoning and land use matters.Local governments oppose being required to make factual findings, Ansbacher said, while private practitioners, who represent landowners and others involved in such issues, support such a mandate. The council’s final report, he said, reflected both positions but said the rules shouldn’t be changed as that could create more problems.The Bar regulation occupying the section’s attention is Rule 4-4.2, which involves contact by an attorney with another person who is already represented by counsel. A special Bar committee has been studying the issue and has made recommendations that will be considered by the Board of Governors in August. That panel has tentatively recommended no change to the rule as it affects criminal cases, but allowing attorneys representing parties suing a government to still address that agency in a public forum.Ansbacher said the section is “basically saying please don’t do anything because it might create more problems.”On other matters, he said the section is continuing to work on a closer relationship with the Real Property, Probate, and Trust Law Section and to improve its CLE offerings. He noted the section’s well-respected Annual Update course will be held August 22-24 at the Amelia Island Plantation.The council is also working on updating the section’s Land Use Law Handbook, regarded by many practitioners as indispensable for that area of law. July 15, 2002 Regular News
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SHARE Email Facebook Twitter Statement Harrisburg, PA – Governor Wolf released the following statement:“We are thankful that Officer Hartnett is alive and not facing life-threatening injuries after being ambushed. We wish him and his family the best during his recovery. This alleged intentional act of violence against an officer seeking to help a fellow citizen is horrifying and has no place in Pennsylvania.”# # #Like Governor Tom Wolf on Facebook: Facebook.com/GovernorWolf January 08, 2016 Governor Wolf Statement on Ambushed Philadelphia Police Officer Jesse Hartnett